A protein with a dual role: Both repair and mutation

Using a specialized protein, all bacteria are capable of rapidly and effectively repairing damage to their DNA from UV. However, this mutation frequency decline (Mfd) protein plays another role and causes mutations. A team1 involving scientists from CNRS, ENS-PSL and supported by Inserm has demonstrated and described this phenomenon. Better understanding of mutations opens up prospects in the fight against resistance to antibiotics and anti-cancer therapies. This study was published in PNAS on 5 April 2021.

Missense Mutation: What Is It, Causes, and More

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The Role p53 Protein in DNA Repair

Unravelling roles of error-prone DNA polymerases in shaping cancer genomes

Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications

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Frontiers APE1/Ref-1 Role in Inflammation and Immune Response

Frontiers Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae

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Chapter 12: DNA Damage and Repair - Chemistry