Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle

Nerve-released ACh increases urinary bladder smooth muscle

Clathrin and GRK2/3 inhibitors block delta opioid receptor

Arrestins differentially regulate histamine- and oxytocin-evoked

Detrusor responses to histamine (100 µM) as a control (left) and

Generalized signaling pathways downstream of histamine receptors

A) Diagram of the urinary tract: kidneys, ureters, urinary bladder

Histamine receptors rapidly desensitize without altering nerve

Nathan Tykocki, PhD - Assistant Professor - Michigan State

Nerve-released ACh increases urinary bladder smooth muscle

Sympathetic nerve fibre distribution in the muscularis mucosae of

Arrestins differentially regulate histamine- and oxytocin-evoked