The majority of breast cancers are oestrogen receptor-positive (ER+). In ER+ cancers, oestrogen acts as a disease driver, so these tumours are likely to be susceptible to endocrine therapy (ET). ET works by blocking the hormone’s synthesis or effect. A significant number of patients diagnosed with breast cancer will have the spread of tumour cells into regional lymph nodes either at the time of diagnosis, or as a recurrence some years later. Patients with node-positive disease have a poorer prognosis and can respond less well to ET. The nodal metastases may be genomically similar or, as is becoming more evident, may differ from the primary tumour. However, nodal metastatic disease is often not assessed, and treatment decisions are almost always based on biomarkers evaluated in the primary tumour. This review will summarise the evidence in the field on ER+, node-positive breast cancer, including diagnosis, treatment, prognosis and predictive tools.
JPM, Free Full-Text, kelly godoy record news
JPM, Free Full-Text, life ring tibia
JPMorgan Chase Email Virus - Removal and recovery steps (updated)
JP MORGAN Application Process 2024
JPMorgan Chase & Co's Organizational Structure [Interactive Chart
JPM, Free Full-Text
JPM, Free Full-Text, life ring tibia
JPM, Free Full-Text
Jamie Dimon's Letter to Shareholders, Annual Report 2022
JPMorgan Chase - Wikipedia
Guide to Retirement J.P. Morgan Asset Management
JPM, Free Full-Text