Pathophysiology of Crohn's disease inflammation and recurrence

Chron’s Disease is a chronic inflammatory intestinal disease, first described at the beginning of the last century. The disease is characterized by the alternation of periods of flares and remissions influenced by a complex pathogenesis in which inflammation plays a key role. Crohn’s disease evolution is mediated by a complex alteration of the inflammatory response which is characterized by alterations of the innate immunity of the intestinal mucosa barrier together with a remodeling of the extracellular matrix through the expression of metalloproteins and increased adhesion molecules expression, such as MAcCAM-1. This reshaped microenvironment enhances leucocytes migration in the sites of inflammation, promoting a TH1 response, through the production of cytokines such as IL-12 and TNF-α. IL-12 itself and IL-23 have been targeted for the medical treatment of CD. Giving the limited success of medical therapies, the treatment of the disease is invariably surgical. This review will highlight the role of inflammation in CD and describe the surgical approaches for the prevention of the almost inevitable recurrence.

Frontiers Comparative diet-gut microbiome analysis in Crohn's disease and Hidradenitis suppurativa

Frontiers The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn's Disease

Crohn's Disease

Crohn's Disease, Inflammatory Bowel Disease

Crohn's disease and clinical management today: How it does?

Crohn's Disease Pathology prsentation unfinshed.pptx

PDF) The Role of Crohn Disease on Breast Cancer Incidence: A Clinical Analysis

Crohn Disease - Gastrointestinal Disorders - Merck Manuals Professional Edition

IJMS, Free Full-Text

JCM, Free Full-Text

PDF) Crohn's Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities

Pathogenesis of Crohn's Disease- and Ulcerative Colitis-Related Strictures - ScienceDirect

Exploring the relationship between Faecalibacterium duncaniae and Escherichia coli in inflammatory bowel disease (IBD): Insights and implications - Computational and Structural Biotechnology Journal