What do we really know about their parents anyway?
Lilo and Stitch fans theorize that Lilo and Nani's parents were in the CIA. Once you consider the evidence, the idea isn't that far-fetched.
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Lilo and Stitch': Were Lilo and Nani's Parents in the CIA?
50+ Strangely Specific yet Convincing Fan Theories About Your Favorite Disney Movies – Page 23
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This Mind-Blowing Fan Theory About Lilo and Stitch Is So Crazy It Might Actually Be True
Agent Bubbles Might Be The Reason That Lilo and Nani's Parents Are Still Alive!
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Nani Pelekai, Disney Wiki