Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

T-cell engineering strategies for tumors with low antigen density, and T- cell survival in the immunosuppressive tumor microenvironment of relapsed/refractory diffuse large B-cell lymphoma – ScienceOpen

PDF] Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

Evan W. Weber CHOP Research Institute

Sung Chang Lee, PhD,Ms (@SungChangLee3) / X

Mechanisms of CAR T cell exhaustion and current counteraction strategies. - Abstract - Europe PMC

CAR-T Cells, PDF, Proteomics

Evan Weber - Assistant Professor - University of Pennsylvania Perelman School of Medicine

Targeting the epigenome to reinvigorate T cells for cancer immunotherapy, Military Medical Research

Epigenetic scarring leaves T cells permanently exhausted

Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

PDF) Transient rest induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

Epigenetic regulation of T cell exhaustion

Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion - ScienceDirect

Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

Dasatinib for treatment of CAR T-cell therapy-related complications